Advances in Pharmacology and Chemotherapy Volume 13 - download pdf or read online

By Silvio Garattini

ISBN-10: 0080581048

ISBN-13: 9780080581040

ISBN-10: 0120329131

ISBN-13: 9780120329137

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Aminonucleoside of Stylomycin Silva et al. (1959) investigated the action of this compound using T. cruzi-infected brain pieces of young chicken kept according to Carrel's hanging-drop technique. The drug proved almost inactive against extracellular forms but strongly affected the intracellular stages which were often destroyed after 48 to 96 hours. This action could not be counteracted by a number of precursors and cofactors of purine nucleotide synthesis. In infected monolayer tissue cultures treated with this compound, intracellular forms were rather rare and almost exclusively formed by amastigote forms, providing evidence of some disturbance in the normal intracellular parasite development (Silva and Kirchner, 1962).

1957). Antibiot. Chernother. ) 7, 13-23. Pan, C. T. (1971). J . Protozool. 18, 556-560. Paul, H. , and Paul, M. F. (1966). In “Experimental Chemotherapy” (R. J. Schnitzer and F. ), Vol. 4, pp. 521-531. Academic Press, New York. Phillips, N. R. (1960). Ann. Trop. Med. Parasitol. 54, 60-70. Pipkin, A. C. (1960). E z p . Parasitol. 9, 167-203. Pizzi, T. (1951). Proc. Sac. Exp. Biol. Med. 78, 643444. Pizzi, T. (1957). “Immunologia de la Enfermedad de Chagas,” 183 pp. Univ. de Chile, Santiago. Pizzi, T.

Mode of Action The mode of action of some compounds active against T . cruzi has been investigated at different levels, such as their role as metabolic inhibitors of culture forms, their activity against extra- and intracellular forms present in infected tissue cultures, and their selective action against bloodstream and/or tissue forms in the living host. A. STUDIES OF METABOLIC INHIBITORS Some drugs whose action had already been analyzed in vitro and had been found to be strong inhibitors of the metabolism in T.

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Advances in Pharmacology and Chemotherapy Volume 13 by Silvio Garattini


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