Download e-book for iPad: 2nd International Adalat® Symposium: New Therapy of Ischemic by W. Lochner (auth.), Professor Dr. Wilhelm Lochner, Wolfgang

By W. Lochner (auth.), Professor Dr. Wilhelm Lochner, Wolfgang Braasch, Günther Kroneberg (eds.)

ISBN-10: 3540074716

ISBN-13: 9783540074717

ISBN-10: 3642662412

ISBN-13: 9783642662416

The First Adalat Symposium held in Tokyo in 1973, offered vital experimental and scientific effects which have been accrued in Europe and Japan with the hot coronary healing agent. the ecu scientists had a chance to debate the issues and effects in my opinion with their eastern colleagues. the second one Adalat Symposium was once held in Amsterdam inside a yr with the aim of bringing jointly more often than not scientists inside Europe. the consequences mentioned in Tokyo were prolonged and supplemented via extra studies. Contributions in uncomplicated technology are offered, yet most crucial are these medical reviews, which aid and expand evidence of the drug's efficacy in people. The editors desire to show their appreciation to all these accountable for contributing to this document and, particularly, to Dr. M. SPENGLER, Dr. F. EBNER and Dr. okay. BRANDAU for his or her editorial support, and to Dr. W. BOTTGER for the instruction of the topic Index. we are hoping that this book should be a beneficial contribution towards conveying info to physicians and scientists. DiisseldorfjWuppertal, Autumn 1975 W. LOCHNER' W BRAASCH' G. KRONEBERG Contents advent: W. LOCHNER current foundation of Coronary remedy: W. LOCHNER. With eleven Figures 2 consultation I. Chemistry and Experimental Pharmacology (Chairmen: A. FLECKENSTEIN and ok. LANDMARK) Pharmacology of Nifedipine: G. KRONEBERG. With eight Figures 12 dialogue feedback 19 The Chemistry of Nifedipine: F. BOSSERT. With nine Figures 20 Pharmacokinetics of Adalat in Animal Experiments: ok. PATZSCHKE, B.

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Discussion Remarks FLECKENSTEIN: In our experiments on anesthetized guinea pigs, we injected verapamil, D 600, and nifedipine and could not detect principal differences in their influence on the atrioventricular (A-V) node. Moreover, Dr. Landmark has carried out similar studies on the A-V node of rats. He also found that nifedipine as well as verapamil increases A-V conduction time. The difference between nifedipine and verapamil is possibly due to a differential degree of reflex activation of the sympathetic system.

The chemically, readly available l,4-dihydropyridines had until then not been pharmacologically or therapeutically studied. Due to their coronary dilatory effect they represent a completely new class of substances. Methyl-l,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nifedipine) proved to be the most interesting and effective of those compounds. CH 3 00C I '" N0 }; 2 CH 3 I I N H HCOOCH BAY a 1040 nifedipine 3 CH 3 26 F. BossERT Chemically, there is no similarity between nifedipine and the other, already known coronary effective compounds, in particular nitrates.

CF-ED 1oo , were devoid ofa detrimental effect on A-V conduction. Acknowledgement. , Osaka, Japan. The invaluable advice given by Professor Emeritus K. HASHIMOTO in the course of the study is gratefully acknowledged. References 1. : Die Wirkung eines Pyrirnidopyrirnidin-Derivates auf die Sauerstoffversorgung des Herzmuskels. -Forsch. ) 9,49-59 (1959). 2. : Cerebral and coronary vascular effects of a symmetrical N,N'-disubstituted hexahydrodiazepine. J. Pharmacol. Exp. 181, 522-528 (1972). 3. : BAY a 1040- ein hochaktiver Ca + + -antagonistischer Inhibitor der elektro-mechanischen Koppelungsprozesse im Warmbliiter-Myokard.

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2nd International Adalat® Symposium: New Therapy of Ischemic Heart Disease by W. Lochner (auth.), Professor Dr. Wilhelm Lochner, Wolfgang Braasch, Günther Kroneberg (eds.)


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